Description

3,3-Difluoro-1-Methylcyclobutane-1-Methamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutane scaffold with fluorine substitution. This compound is valued for its role in modulating the physicochemical and metabolic properties of active pharmaceutical ingredients (APIs), particularly in drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutics in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially those targeting protein kinases and G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce conformational rigidity and improve metabolic stability via fluorine incorporation.
• API Development: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Chemical Biology Probes: Employed in the creation of specialized chemical probes for investigating biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale manufacturing under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	3,3-Difluoro-1-Methylcyclobutane-1-Methamine Hydrochloride
CAS No.	1523606-30-5
Molecular Formula	C7H14ClF2N
Molecular Weight	185.64 g/mol
Synonyms	1-Methyl-3,3-difluorocyclobutane-1-methanamine hydrochloride; 3,3-Difluoro-1-methylcyclobutanemethylamine hydrochloride; 1-(Aminomethyl)-3,3-difluoro-1-methylcyclobutane hydrochloride; (3,3-Difluoro-1-methylcyclobutyl)methanamine hydrochloride; 1-Methyl-3,3-difluorocyclobutyl-1-methylamine HCl; 1523606-30-5; Cyclobutanemethanamine, 3,3-difluoro-1-methyl-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-1-Methylcyclobutane-1-Methamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, ensuring compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.