Description

Methyl 3,3-Difluoro-1-Methylcyclobutanecarboxylate is a high-value fluorinated cyclobutane derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a difluorinated cyclobutane ring, makes it a versatile building block for introducing conformational rigidity and fluorine atoms into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to optimize the potency, metabolic stability, and bioavailability of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated cyclobutane moiety can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers and advanced materials with tailored properties such as chemical resistance or specific dielectric constants.
• Ligand and Catalyst Development: Employed in organometallic chemistry and catalysis research to create novel chiral ligands or metal complexes.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions, ring-strain chemistry, and the stereoelectronic effects of the gem-difluoro group on a cyclobutane scaffold.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	Methyl 3,3-Difluoro-1-Methylcyclobutanecarboxylate
CAS No.	1523571-06-3
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	Methyl 3,3-difluoro-1-methylcyclobutanecarboxylate; 1-Methylcyclobutane-1-carboxylic acid, 3,3-difluoro-, methyl ester; 3,3-Difluoro-1-methylcyclobutanecarboxylic acid methyl ester; Methyl 3,3-difluoro-1-methylcyclobutanecarboxylate; Methyl 1-methyl-3,3-difluorocyclobutanecarboxylate; 1523571-06-3; MFCD32815511
EINECS	Contact for details

Quality Control

Our production of Methyl 3,3-Difluoro-1-Methylcyclobutanecarboxylate adheres to stringent in-process and final release controls to ensure batch-to-batch consistency and high purity. Quality is verified using advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP and ISO 9001 standards for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed and stored upright away from heat sources and incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.