Description

2-Fluoro-5-(Trifluoromethoxy)Benzyl Chloride is a high-value fluorinated benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, is essential for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS, oncology, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine motifs enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Functional Material Development: Employed in creating specialty polymers and organic electronic materials that require specific electronic and surface properties.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to introduce complex aryl motifs.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethoxy)Benzyl Chloride
CAS No.	1517586-69-4
Molecular Formula	C9H5ClF4O
Molecular Weight	240.58 g/mol
Synonyms	1-(Chloromethyl)-2-fluoro-5-(trifluoromethoxy)benzene; α-Chloro-2-fluoro-α-(trifluoromethoxy)toluene; 2-Fluoro-α-(chloromethyl)-5-(trifluoromethoxy)benzene; (2-Fluoro-5-(trifluoromethoxy)phenyl)methyl chloride; Benzene, 1-(chloromethyl)-2-fluoro-5-(trifluoromethoxy)-; 5-(Trifluoromethoxy)-2-fluorobenzyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(Trifluoromethoxy)Benzyl Chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) documenting identity, purity, and related substances is provided with each shipment. We support development projects with capabilities for custom purity grades (e.g., >98%, >99%) to meet specific research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.