Description

4-Hydroxy-6-(Trifluoromethyl)-2H-Chromen-2-One is a high-value, fluorinated coumarin derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring a trifluoromethyl group and a hydroxylated coumarin core, makes it a versatile building block for developing novel compounds with enhanced properties. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to incorporate fluorinated motifs for improved bioactivity, stability, or material characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group can enhance metabolic stability and membrane permeability.
• Agrochemical Research: Building block for developing next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity of the coumarin scaffold and the lipophilicity imparted by the fluorine atoms.
• Organic Light-Emitting Diodes (OLEDs): Used in the research and development of electron-transport materials or emissive layer dopants for display and lighting technologies, benefiting from the photophysical properties of the coumarin system.
• Fluorescent Probe & Sensor Development: Serves as a core structure for creating sensitive fluorescent probes and chemosensors used in biochemical assays, environmental monitoring, and diagnostic imaging due to its inherent fluorescence.
• Material Science Additive: Investigated as a monomer or additive for specialty polymers and coatings to impart specific optical, surface, or durability characteristics.
• Academic & Contract Research: A valuable reagent for synthetic methodology development, medicinal chemistry programs, and exploring structure-activity relationships (SAR) in both industrial and academic settings.

Basic Information

Item	Details
Product Name	4-Hydroxy-6-(Trifluoromethyl)-2H-Chromen-2-One
CAS No.	1517131-31-5
Molecular Formula	C10H5F3O3
Molecular Weight	230.14 g/mol
Synonyms	6-(Trifluoromethyl)-4-hydroxy-2H-chromen-2-one; 4-Hydroxy-6-(trifluoromethyl)coumarin; 6-Trifluoromethyl-4-hydroxycoumarin; 4-Hydroxy-6-trifluoromethylcoumarin; 2H-1-Benzopyran-2-one, 4-hydroxy-6-(trifluoromethyl)-; 4-Hydroxy-6-(trifluoromethyl)-2H-1-benzopyran-2-one
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-6-(Trifluoromethyl)-2H-Chromen-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), related substances, and physical characteristics. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable performance in your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect this light-sensitive compound from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.