Description

n-Cyclopentyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, which is critical for modern cross-coupling reactions in medicinal chemistry. This compound is essential for the efficient synthesis of complex molecules, enabling the rapid exploration of chemical space and the development of new therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for the development of kinase inhibitors and other small-molecule active pharmaceutical ingredients (APIs).

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key building block for constructing biaryl and heterobiaryl structures in drug candidates.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of targeted kinase inhibitors and other novel therapeutic compounds.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in early-stage drug discovery programs.
• Chemical Biology Probes: Used to create labeled or tagged molecules for studying biological pathways and target engagement.
• Agrochemical Development: Potential intermediate in the research and synthesis of new active ingredients for crop protection.
• Material Science Research: Can be employed in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) requiring specific boronic acid derivatives.

Basic Information

Product Name	n-Cyclopentyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide
CAS No.	1509931-88-7
Molecular Formula	C20H29BN2O3
Molecular Weight	356.27 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopentylnicotinamide; N-Cyclopentyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopentyl-; 1509931-88-7; 5-(Pinacolatoboryl)-N-cyclopentylnicotinamide; Nicotinamide, N-cyclopentyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our n-Cyclopentyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for demanding research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronate ester group. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.