Description

tert-Butyl 3-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Azetidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate and building block designed for modern synthetic chemistry. This compound matters because it integrates a protected azetidine moiety with a boronic ester functional group, enabling efficient cross-coupling reactions and the construction of complex nitrogen-containing heterocycles. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: The tetramethyl-1,3,2-dioxaborolane (pinacol boronic ester) group serves as a stable, versatile handle for palladium-catalyzed cross-coupling with aryl/heteroaryl halides.
• Azetidine Chemistry: The protected 3-phenoxyazetidine scaffold is valuable for introducing constrained four-membered nitrogen heterocycles into molecular architectures to modulate physicochemical and pharmacological properties.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science & OLED Development: Acts as a precursor for creating novel organic electronic materials, including charge-transport layers and emissive materials in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tool compounds for studying biological pathways and protein function.

Basic Information

Product Name	tert-Butyl 3-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Azetidine-1-Carboxylate
CAS No.	1505515-91-2
Molecular Formula	C20H30BNO5
Molecular Weight	375.27 g/mol
Synonyms	1-Boc-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)azetidine; tert-Butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)azetidine-1-carboxylate; 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]azetidine-1-carboxylic acid tert-butyl ester; Azetidine, 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-, 1-(1,1-dimethylethyl) ester; Boc-3-(4-Pinacolborylphenoxy)azetidine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Azetidine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.