Description

(2-Amino-5-(Trifluoromethyl)Phenyl)(2-Fluorophenyl)Methanone is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethyl and amino-substituted benzophenone core structure. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas such as kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates, especially those targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• API Development: Integral in the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for investigating biological pathways and target validation.
• Custom Synthesis: Provided for contract research and manufacturing organizations (CROs/CMOs) requiring bespoke fluorinated aromatic building blocks.
• Agrochemical Research: Potential application as an intermediate in the development of advanced agrochemicals due to the stability imparted by the fluorine atoms.

Basic Information

Product Name	(2-Amino-5-(Trifluoromethyl)Phenyl)(2-Fluorophenyl)Methanone
CAS No.	1504465-76-2
Molecular Formula	C14H9F4NO
Molecular Weight	283.23 g/mol
Synonyms	2-Amino-5-(trifluoromethyl)phenyl 2-fluorophenyl ketone; 2'-Fluoro-2-amino-5'-(trifluoromethyl)benzophenone; 1-(2-Amino-5-(trifluoromethyl)phenyl)-2-fluoroethanone (incorrect but common misnomer); (2-Amino-α,α,α-trifluoro-m-tolyl)(2-fluorophenyl)methanone; 2-Fluoro-2'-amino-α,α,α-trifluoromethylbenzophenone; Benzophenone, 2'-fluoro-2-amino-5'-(trifluoromethyl)-; CAS 1504465-76-2
EINECS	Contact for details

Quality Control

Our (2-Amino-5-(Trifluoromethyl)Phenyl)(2-Fluorophenyl)Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.