Description

5'-Bromo-2'-Fluoro-4'-Hydroxyacetophenone is a high-purity, multi-functional aromatic ketone building block of significant importance in advanced organic synthesis. Its unique halogenated and hydroxylated structure makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the bromo and fluoro substituents can enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for the synthesis of fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and charge-transport materials due to its electron-deficient aromatic core.
• Chemical Research & Development: A valuable reagent for method development, cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), and exploring new synthetic pathways in academic and industrial R&D labs.
• Fine Chemical Production: Acts as an intermediate for the manufacture of specialty dyes, pigments, and UV absorbers.

Basic Information

Product Name	5'-Bromo-2'-Fluoro-4'-Hydroxyacetophenone
CAS No.	1503357-95-6
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	1-(5-Bromo-2-fluoro-4-hydroxyphenyl)ethan-1-one; 5-Bromo-2-fluoro-4-hydroxyacetophenone; 4'-Hydroxy-5'-bromo-2'-fluoroacetophenone; 2-Fluoro-5-bromo-4-hydroxyacetophenone; 4-Acetyl-2-bromo-5-fluorophenol; 1-Acetyl-5-bromo-2-fluoro-4-hydroxybenzene; 5-Bromo-2-fluoro-4-acetylphenol
EINECS	Contact for details

Quality Control

Our 5'-Bromo-2'-Fluoro-4'-Hydroxyacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.