Description

1-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-C]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a pyrrolopyridine core with a boronic ester protecting group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for oncology, neurology, and antiviral research.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the pyrrolopyridine scaffold.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the introduction of the 1H-pyrrolo[2,3-c]pyridine moiety into complex molecular architectures.
• Kinase Inhibitor Development: Foundational component in the creation of potent and selective kinase inhibitors targeting various disease pathways.
• Chemical Biology Probes: Utilized in the development of tool compounds for target identification and validation studies.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of candidate drugs.

Basic Information

Product Name	1-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-C]Pyridine
CAS No.	1501153-45-2
Molecular Formula	C15H21BN2O2
Molecular Weight	272.15 g/mol
Synonyms	1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine; 1H-Pyrrolo[2,3-c]pyridine, 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrrolo[2,3-c]pyridine; 1-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine; 1501153-45-2; Boronic ester of 1-methyl-1H-pyrrolo[2,3-c]pyridine; 1-Methylpyrrolo[2,3-c]pyridine-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-C]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, supporting your regulatory and compliance needs from research through to commercial development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.