Description

4-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional heterocyclic building block containing a protected pyrazole core and a pinacol boronate ester group. This compound matters as a critical intermediate in modern synthetic chemistry, enabling precise carbon-carbon bond formation via cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex molecular architectures in drug discovery and advanced material science.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides requiring specific heterocyclic motifs.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLEDs and semiconductors, where conjugated systems are essential.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for target identification and validation.
• Academic & Contract Research: A versatile reagent for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	4-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1492954-33-2
Molecular Formula	C15H25BN2O3
Molecular Weight	292.18 g/mol
Synonyms	4-Methyl-1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 4-methyl-1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-Methyl-1-THP-5-(pinacol boronate)-pyrazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; THP-Protected Pyrazole Boronic Ester; 4-Methyl-1-(THP)-5-(Bpin)-pyrazole; Pyrazole Boronate Ester Intermediate; 1492954-33-2
EINECS	Contact for details

Quality Control

Our 4-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.