Description

1-Butyl-1H-Pyrazole-4-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis. CAS No. 1488423-70-6.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heteroaryl motifs in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific pyrazole-based structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and enzyme inhibitors for target identification and validation studies.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel ligands and catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A valuable building block for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	1-Butyl-1H-Pyrazole-4-Boronic Acid, Pinacol Ester
CAS No.	1488423-70-6
Molecular Formula	C13H23BN2O2
Molecular Weight	250.15 g/mol
Synonyms	1-Butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Butyl-1H-pyrazole-4-boronic acid pinacol ester; 1-Butyl-4-(pinacolboranyl)-1H-pyrazole; 1-Butyl-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Butylpyrazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-butyl-1H-pyrazole; Pyrazole-4-boronic acid, 1-butyl-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Butyl-1H-Pyrazole-4-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We employ advanced analytical techniques, including HPLC, NMR, and GC-MS, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.