Description

2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is a high-value, multi-functional boronic ester derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and materials science research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific phenolic-boronate motifs.
• Material Science & OLED Development: Serves as a monomer or building block for creating organic semiconductors, light-emitting materials, and advanced polymers.
• Ligand & Catalyst Design: Utilized in the preparation of sophisticated ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Incorporated into molecular probes for studying biological processes and protein interactions.
• Polymer Functionalization: Enables the introduction of phenol and boronate ester functionalities into polymer backbones for specialty materials.

Basic Information

Product Name	2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
CAS No.	1487353-52-5
Molecular Formula	C14H21BO3
Molecular Weight	248.13 g/mol
Synonyms	4-Hydroxy-2,5-dimethylphenylboronic acid pinacol ester; 2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; (4-Hydroxy-2,5-dimethylphenyl)boronic acid pinacol ester; 2,5-Dimethyl-4-(pinacolatoboryl)phenol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dimethylphenol; Phenol, 2,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.