Description

2,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a protected phenol boronic acid, offering enhanced stability and solubility for cross-coupling reactions compared to the free boronic acid. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl structures, a common motif in active pharmaceutical ingredients (APIs) and organic electronic materials.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the multi-step synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated bidentate or polydentate ligands for transition metal catalysts, enhancing reaction selectivity and efficiency.
• Polymer and Material Science: Incorporated into monomers for creating functionalized polymers, liquid crystals, or organic semiconductors with tailored electronic or optical properties.
• Agrochemical Research: Employed in the discovery and development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
CAS No.	1487353-47-8
Molecular Formula	C14H21BO3
Molecular Weight	248.13 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dimethylphenol; 2,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)phenol; 2,3-Dimethylphenol-4-boronic acid pinacol ester; 4-Pinacolatoboryl-2,3-dimethylphenol; Phenol, 2,3-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; B-(3,4-Dimethyl-2-hydroxyphenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2,3-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.