Description

1-Methyl-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Ethynyl]-1H-Pyrazole is a high-value, functionalized pyrazole derivative containing a protected boronic ester group, making it a versatile and critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex heterocyclic cores.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boron-containing coupling partner for the formation of carbon-carbon bonds, enabling the construction of biaryl and conjugated systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate pyrazole motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular structure is critical.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.

Basic Information

Product Name	1-Methyl-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Ethynyl]-1H-Pyrazole
CAS No.	1487353-22-9
Molecular Formula	C₁₄H₂₁BN₂O₂
Molecular Weight	260.14 g/mol
Synonyms	1-Methyl-4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethynyl)-1H-pyrazole; 4-Ethynyl-1-methyl-1H-pyrazole pinacol boronate; 1-Methyl-4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethynyl)-1H-pyrazole; 1-Methyl-4-(pinacolatoborylethynyl)pyrazole; 1-Methyl-4-ethynylpyrazole pinacol boronic ester; Pyrazole boronic ester derivative; Borylated pyrazole alkyne
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Ethynyl]-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.