Description

1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-3-(Trifluoromethyl)-1H-Pyrazole is a high-value, synthetically versatile organoboron building block. This compound is critical for facilitating efficient cross-coupling reactions, particularly in the synthesis of complex pharmaceutical intermediates and advanced materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides that require the incorporation of trifluoromethylpyrazole and boronic ester functionalities.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes, leveraging its borylation for bioconjugation strategies.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-purity boronic ester derivatives.

Basic Information

Product Name	1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-3-(Trifluoromethyl)-1H-Pyrazole
CAS No.	1486485-54-4
Molecular Formula	C17H20BF3N2O2
Molecular Weight	352.16 g/mol
Synonyms	[4-[[3-(Trifluoromethyl)-1H-pyrazol-1-yl]methyl]phenyl]boronic acid, pinacol ester; 1-[[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-3-(trifluoromethyl)-1H-pyrazole; 3-(Trifluoromethyl)-1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-pyrazole; (4-((3-(Trifluoromethyl)-1H-pyrazol-1-yl)methyl)phenyl)boronic acid pinacol ester; B-[4-[[3-(Trifluoromethyl)-1H-pyrazol-1-yl]methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1486485-54-4; Boronic acid, B-[4-[[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-3-(Trifluoromethyl)-1H-Pyrazole adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR (1H, 13C, 11B), HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.