Description

1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]-1H-Pyrazole, 2-{3-[(1H-Pyrazol-1-Yl)Methyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value, bifunctional boronic ester derivative that serves as a critical advanced pharmaceutical intermediate (API) and versatile Suzuki-Miyaura cross-coupling building block. Its molecular architecture, featuring two distinct reactive sites, enables the efficient synthesis of complex, functionalized biaryl structures essential in modern drug discovery. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutics, agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting various disease areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds between aryl/heteroaryl groups under mild conditions, crucial for constructing complex molecules.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Precursor for organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and other advanced organic electronic materials.
• Ligand Synthesis: Serves as a precursor for creating novel bidentate ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.

Basic Information

Item	Details
Product Name	1-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]-1H-Pyrazole, 2-{3-[(1H-Pyrazol-1-Yl)Methyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1486485-43-1
Molecular Formula	C20H28B2N4O4
Molecular Weight	398.09 g/mol
Synonyms	1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-1H-pyrazole; 2-[3-(1H-Pyrazol-1-ylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-pyrazole; Bifunctional Pyrazole Boronic Ester; 1,1'-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(methanediyl))dipyrazole (alternative representation); 1486485-43-1; CAS 1486485-43-1
EINECS	Contact for details

Quality Control

Our production of this high-purity boronic ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis via HPLC, NMR (1H, 13C, 11B), and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications, and our quality system is designed to meet the exacting standards of global R&D and manufacturing partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent hydrolysis and maintain purity. For long-term storage, consider storing under an inert gas blanket in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.