Description

1,1-Dimethyl 3-Hydroxycyclobutane-1,1-Dicarboxylate is a high-purity, functionalized cyclobutane derivative serving as a versatile chiral building block and synthetic intermediate. Its value lies in its unique strained ring structure and multiple reactive sites, enabling the synthesis of complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Asymmetric Synthesis: Utilized as a precursor for constructing stereodefined, fused-ring systems and spirocyclic compounds in advanced organic synthesis.
• Ligand and Catalyst Development: Serves as a scaffold for developing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with specific thermal or mechanical properties derived from the cyclobutane ring.
• Agrochemical Synthesis: Employed in the research and development of new generation herbicides and plant growth regulators with novel modes of action.
• Academic & R&D: A valuable reagent for methodological studies in ring-opening, functionalization, and annulation reactions of strained carbocycles.

Basic Information

Product Name	1,1-Dimethyl 3-Hydroxycyclobutane-1,1-Dicarboxylate
CAS No.	1484536-54-0
Molecular Formula	C9H14O5
Molecular Weight	202.20 g/mol
Synonyms	Dimethyl 3-hydroxycyclobutane-1,1-dicarboxylate; 3-Hydroxycyclobutane-1,1-dicarboxylic acid dimethyl ester; 1,1-Cyclobutanedicarboxylic acid, 3-hydroxy-, dimethyl ester; 3-Hydroxy-1,1-cyclobutanedicarboxylic Acid Dimethyl Ester; 1,1-Dimethyl 3-hydroxycyclobutane-1,1-dicarboxylate; 3-Hydroxycyclobutane-1,1-dicarboxylate dimethyl ester
EINECS	Contact for details

Quality Control

Our 1,1-Dimethyl 3-Hydroxycyclobutane-1,1-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.