Description

2-(4-Methylpiperazin-1-Yl)-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is a high-value pharmaceutical intermediate and building block featuring a boronic ester pinacol group. This compound is critical for modern drug discovery, particularly in the synthesis of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs) and bioconjugates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety serves as a crucial coupling partner for forming carbon-carbon bonds with aryl halides, enabling the construction of complex biaryl structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or affinity probes for biochemical and diagnostic applications.
• Chemical Biology Tool: Employed in the development of chemical probes to study biological pathways and protein function.
• Custom Synthesis: Serves as a specialized starting material for contract research organizations (CROs) and custom synthesis providers.

Basic Information

Product Name	2-(4-Methylpiperazin-1-Yl)-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide
CAS No.	1480399-95-8
Molecular Formula	C21H34BN3O3
Molecular Weight	387.33 g/mol
Synonyms	N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(4-methyl-1-piperazinyl)acetamide; 2-(4-Methylpiperazin-1-yl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 4-(4-Methylpiperazin-1-yl)acetophenone-4-boronic acid pinacol ester (common name variant); 1480399-95-8; 2-(4-Methyl-1-piperazinyl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; Boronic ester intermediate with methylpiperazine; Acetamide, 2-(4-methyl-1-piperazinyl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
EINECS	Contact for details

Quality Control

Our 2-(4-Methylpiperazin-1-Yl)-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.