Description

4,4,5,5-Tetramethyl-2-(2-((o-Tolyloxy)Methyl)Phenyl)-1,3,2-Dioxaborolane is a specialized organoboron compound, specifically a pinacol boronic ester derivative, with the CAS number 1473452-58-2. This chemical serves as a crucial advanced synthetic intermediate in modern organic synthesis, enabling the formation of carbon-carbon and carbon-heteroatom bonds. It is primarily utilized by pharmaceutical R&D and agrochemical laboratories for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific aryl-boron motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and target engagement.
• Academic & Industrial R&D: A versatile reagent for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(2-((o-Tolyloxy)Methyl)Phenyl)-1,3,2-Dioxaborolane
CAS No.	1473452-58-2
Molecular Formula	C20H25BO3
Molecular Weight	324.22 g/mol
Synonyms	2-[2-[(2-Methylphenoxy)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-((o-Tolyloxy)methyl)phenyl)boronic acid pinacol ester; o-Tolyloxymethylphenylboronic acid pinacol ester; B-[2-[(2-Methylphenoxy)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(2-((o-Tolyloxy)Methyl)Phenyl)-1,3,2-Dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis including HPLC for purity and identity confirmation via NMR and IR spectroscopy. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.