Description

4-Fluoro-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Benzenesulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining a sulfonamide group with a pinacol boronate ester. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and biotechnology industries for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates targeting various disease pathways.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety serves as a crucial handle for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Agrochemical Synthesis: Intermediate in the development of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological processes and target validation.
• Material Science Research: Potential precursor for the synthesis of organic electronic materials and polymers.

Basic Information

Product Name	4-Fluoro-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Benzenesulfonamide
CAS No.	1469930-84-4
Molecular Formula	C18H21BFNO4S
Molecular Weight	377.24 g/mol
Synonyms	4-Fluoro-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzenesulfonamide; N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-fluorobenzenesulfonamide; 4-Fluoro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzene-1-sulfonamide; 4-Fluoro-N-(4-(pinacolboryl)phenyl)benzenesulfonamide; Benzenesulfonamide, 4-fluoro-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 1469930-84-4; Boric acid, [4-[[(4-fluorophenyl)sulfonyl]amino]phenyl]-, 2,2-dimethyl-1,3-propanediyl ester
EINECS	Contact for details

Quality Control

Our 4-Fluoro-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Benzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect the boronate ester functionality from moisture. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.