Description

4-{[3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-1λ-Thiomorpholine-1,1-Dione is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, making it a critical building block for modern synthetic chemistry. This compound is specifically designed for applications requiring precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl and heterobiaryl structures, which are prevalent scaffolds in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex aryl-aryl linkages.
• Material Science & OLED Development: Serves as a building block for creating organic light-emitting diode (OLED) materials and advanced polymers with tailored electronic properties.
• Chemical Biology & Probe Synthesis: Facilitates the labeling and modification of biomolecules for diagnostic and research tools.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities to support route scouting and manufacturing campaigns.

Basic Information

Product Name	4-{[3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-1λ-Thiomorpholine-1,1-Dione
CAS No.	1469440-25-2
Molecular Formula	C₁₇H₂₃BFNO₄S
Molecular Weight	367.24 g/mol
Synonyms	4-[(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)thiomorpholine 1,1-dioxide; 2-[2-Fluoro-4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-((3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)thiomorpholine 1,1-dioxide; CAS 1469440-25-2; Thiomorpholine-1,1-dioxide boronic ester derivative; Fluorinated phenylboronic acid pinacol ester intermediate.
EINECS	Contact for details

Quality Control

Our production of 4-{[3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}-1λ-Thiomorpholine-1,1-Dione adheres to stringent quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with client specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.