Description

2-(4-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Phenyl)-1,1,1-Trifluoropropan-2-Ol CAS NO 1467061-57-9 is a high-value, advanced pharmaceutical intermediate featuring a unique trifluoromethyl-substituted tertiary alcohol linked to a protected boronic ester moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily needed by R&D and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester functionality serves as a key coupling partner for constructing biaryl and heterobiaryl scaffolds central to many drug candidates.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Acts as a precursor for developing novel herbicides and fungicides that leverage the physicochemical properties of the trifluoromethyl group.
• Material Science: Potential monomer or additive for creating specialty polymers with specific optical or electronic properties.
• Fluorine Chemistry Library Synthesis: A valuable scaffold for constructing diverse compound libraries in drug discovery programs focused on fluorine-containing molecules.
• Ligand and Catalyst Development: Can be utilized to develop novel bidentate ligands for asymmetric catalysis.

Basic Information

Item	Details
Product Name	2-(4-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Phenyl)-1,1,1-Trifluoropropan-2-Ol
CAS No.	1467061-57-9
Molecular Formula	C15H20BF3O3
Molecular Weight	316.13 g/mol
Synonyms	2-[4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]-1,1,1-trifluoropropan-2-ol; 1,1,1-Trifluoro-2-[4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]propan-2-ol; 2-(4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)-1,1,1-trifluoro-2-propanol; 4-(1,1,1-Trifluoro-2-hydroxypropan-2-yl)phenylboronic acid, 5,5-dimethyl-1,3,2-dioxaborinane ester; 1467061-57-9; Trifluoromethyl-substituted boronic ester alcohol; 2-(4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)hexafluoroisopropanol analog
EINECS	Contact for details

Quality Control

Our 2-(4-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Phenyl)-1,1,1-Trifluoropropan-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 11B), HPLC, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.