Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate and building block featuring a versatile indazole core and a protected boronic ester functional group. This compound matters for its critical role in modern medicinal chemistry, specifically in Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex, biologically active molecules. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new drug candidates and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS research.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures common in modern drug molecules.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Employed in the creation of organic electronic materials, such as OLEDs and organic semiconductors, due to its conjugated indazole system.
• Chemical Biology & Proteomics: Utilized as a molecular probe or tag in the study of biological pathways and protein interactions.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries via high-throughput synthesis for screening against biological targets.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole-3-Carbonitrile
CAS No.	1463055-84-6
Molecular Formula	C₁₄H₁₆BN₃O₂
Molecular Weight	269.11 g/mol
Synonyms	1H-Indazole-3-carbonitrile, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carbonitrile; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carbonitrile; 5-Pinacolatoboryl-1H-indazole-3-carbonitrile; 3-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; B-(3-Cyano-1H-indazol-5-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a desiccator to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.