Description

1,6-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex drug candidates. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small molecule therapeutics, particularly for oncology and central nervous system targets.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing carbon-carbon bonds in the synthesis of novel drug molecules and complex organic compounds.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and target engagement.
• Agrochemical Synthesis: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science Research: Can be utilized in the synthesis of organic electronic materials and advanced polymers.

Basic Information

Product Name	1,6-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
CAS No.	1463055-05-1
Molecular Formula	C15H21BN2O2
Molecular Weight	272.15 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dimethyl-1H-indazole; 1,6-Dimethyl-1H-indazole-5-boronic acid pinacol ester; 1,6-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1463055-05-1; 1H-Indazole, 1,6-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 1,6-dimethyl-1H-indazole-5-boronate
EINECS	Contact for details

Quality Control

Our 1,6-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.