Description

7-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one is a high-value pharmaceutical intermediate and versatile synthetic building block. This compound is critical for modern medicinal chemistry, enabling the efficient construction of complex molecules through cross-coupling reactions. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boron-containing reagent for constructing biaryl and heterobiaryl structures in drug candidates.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel indole-based therapeutic agents.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies for lead optimization.
• Organic Synthesis: Enables the introduction of the 7-fluoroindolin-2-one scaffold into more complex molecular architectures.
• Agrochemical Development: Potential intermediate in the research and synthesis of new crop protection agents.
• Material Science Precursor: Can be utilized in the development of organic electronic materials and ligands for catalysis.

Basic Information

Product Name	7-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
CAS No.	1463054-13-8
Molecular Formula	C₁₄H₁₇BFNO₃
Molecular Weight	277.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7-fluoroindolin-2-one; 7-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-2-one; 7-Fluoro-5-(pinacolatoboryl)indolin-2-one; 7-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2(3H)-one; 7-Fluoro-5-(pinacol boronate)indolin-2-one; 1463054-13-8; 7-Fluoro-5-(pinacolato)borylindolin-2-one; 7-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-indolinone
EINECS	Contact for details

Quality Control

Our 7-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.