Description

1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine Hydrochloride is a high-value, protected boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to build novel molecular scaffolds for drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and other therapeutic agents.
• Suzuki-Miyaura Cross-Coupling: Enables the efficient and selective formation of biaryl and other C-C bonds, crucial for constructing complex molecular architectures.
• Medicinal Chemistry Research: Used in high-throughput screening and lead optimization to create diverse compound libraries for biological evaluation.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalysis.
• Process Chemistry & Scale-up: Suitable for use in route development from laboratory to pilot plant scale, thanks to its stability as a protected boronate ester.

Basic Information

Product Name	1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine Hydrochloride
CAS No.	1462950-92-0
Molecular Formula	C16H29BClNO2
Molecular Weight	313.67 g/mol
Synonyms	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine hydrochloride; 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester hydrochloride; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1,2,3,6-tetrahydropyridine HCl; 1-Methyl-4-(pinacolatoboryl)-1,2,3,6-tetrahydropyridine hydrochloride; N-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in cGMP and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.