Description

trans-3-Fluoro-3-Methylcyclobutane-1-Carboxylic Acid CAS NO 1455037-43-0 is a high-purity, fluorinated cyclobutane derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a carboxylic acid group and a fluorine atom on a strained cyclobutane ring, makes it a valuable scaffold for introducing conformational rigidity and modulating physicochemical properties in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and anti-infectives.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the fluorine atom and rigid cyclobutane core can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Precursor: Employed in the research of specialty polymers and advanced materials, where fluorinated cyclic compounds can impart unique thermal and chemical resistance.
• Chemical Biology Probe: Utilized as a building block for synthesizing molecular probes and labeled compounds to study biological mechanisms and enzyme interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards for clinical and commercial supply.

Basic Information

Product Name	trans-3-Fluoro-3-Methylcyclobutane-1-Carboxylic Acid
CAS No.	1455037-43-0
Molecular Formula	C7H9FO2
Molecular Weight	144.14 g/mol
Synonyms	(1R,3S)-3-Fluoro-3-methylcyclobutane-1-carboxylic acid; (1S,3R)-3-Fluoro-3-methylcyclobutane-1-carboxylic acid; trans-3-Fluoro-3-methylcyclobutane carboxylic acid; 3-Fluoro-3-methylcyclobutane-1-carboxylic acid; 3-Methyl-3-fluorocyclobutane-1-carboxylic acid; Fluoromethylcyclobutane carboxylic acid; Cyclobutanecarboxylic acid, 3-fluoro-3-methyl-, trans-
EINECS	Contact for details

Quality Control

Our trans-3-Fluoro-3-Methylcyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for advanced research and process development. A detailed Certificate of Analysis (COA) providing identity, purity (typically ≥97% by HPLC), and impurity profile is supplied with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.