Description

4-(1-Boc-Pyrrolidin-2-Yl)Benzeneboronic Acid Pinacol Ester is a high-value, protected boronic acid ester building block crucial for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those containing substituted pyrrolidine and aryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, protected boronic acid derivative for forming carbon-carbon bonds with aryl/heteroaryl halides, a cornerstone of medicinal chemistry.
• Peptidomimetic & PROTAC Development: Used in constructing sophisticated molecules that mimic peptides or act as proteolysis-targeting chimeras for targeted protein degradation.
• Agrochemical Research: Employed in the discovery and synthesis of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science & Ligand Synthesis: Useful for creating novel organic ligands for catalysis or functional organic materials.
• Academic & Contract Research: A valuable reagent for exploratory research in synthetic methodology and complex natural product synthesis.

Basic Information

Product Name	4-(1-Boc-Pyrrolidin-2-Yl)Benzeneboronic Acid Pinacol Ester
CAS No.	1454815-08-7
Molecular Formula	C21H32BNO4
Molecular Weight	373.30 g/mol
Synonyms	4-(1-Boc-2-Pyrrolidinyl)Benzeneboronic Acid Pinacol Ester; 4-(1-(tert-Butoxycarbonyl)-2-pyrrolidinyl)benzeneboronic Acid Pinacol Ester; 4-(N-Boc-pyrrolidin-2-yl)phenylboronic Acid Pinacol Ester; 4-(1-Boc-pyrrolidin-2-yl)phenylboronic Acid Pinacol Ester; 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester; tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 4-(1-Boc-Pyrrolidin-2-Yl)Benzeneboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.