Description

4-(5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)Phenylboronic Acid Pinacol Ester is a sophisticated bifunctional building block that combines a boronic ester moiety with a 1,2,4-oxadiazolone heterocycle. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical discovery and advanced materials science. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel drug candidates and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds, a common scaffold in drug discovery for oncology, CNS, and metabolic diseases.
• Agrochemical Research: Used to create novel active ingredients with potential herbicidal, fungicidal, or insecticidal properties.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs or organic photovoltaics, due to its conjugated system and functional handles.
• Chemical Biology & Proteomics: Can be utilized as a probe or linker in the development of activity-based protein profiling (ABPP) reagents or bioconjugation strategies.
• Library Synthesis: Enables high-throughput parallel synthesis for creating diverse compound libraries in medicinal chemistry programs.
• Ligand Development: The oxadiazolone ring can act as a coordinating group or be further modified to create novel catalysts and ligands for transition metal catalysis.

Basic Information

Product Name	4-(5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)Phenylboronic Acid Pinacol Ester
CAS No.	1454814-36-8
Molecular Formula	C15H19BN2O4
Molecular Weight	302.14 g/mol
Synonyms	3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,2,4-oxadiazol-5(4H)-one; 4-(5-Oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-benzeneboronic acid pinacol ester; [4-(5-Oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]boronic acid pinacol ester; B-[4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]boronic acid pinacol ester; Pinacol 4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzeneboronate; 4-(1,2,4-Oxadiazol-5-on-3-yl)phenylboronic acid pinacol ester; CAS 1454814-36-8
EINECS	Contact for details

Quality Control

Our 4-(5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.