Description

1-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Thiazol-2-Yl]Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic ester-protected thiazole scaffold. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex bioactive molecules and functional materials. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new drug candidates and specialty chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing building block for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Employed in the creation of new fungicides and herbicides that leverage the thiazole moiety for biological activity.
• Material Science Research: Acts as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probes: Utilized in the development of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Library Synthesis for Drug Discovery: A valuable reagent for generating diverse compound libraries via high-throughput parallel synthesis.

Basic Information

Item	Details
Product Name	1-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Thiazol-2-Yl]Ethanone
CAS No.	1452577-24-0
Molecular Formula	C11H16BNO3S
Molecular Weight	253.13 g/mol
Synonyms	2-Acetyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazol-2-yl]ethan-1-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole-2-yl methyl ketone; Thiazole boronic acid pinacol ester, acetyl derivative; CAS 1452577-24-0; Acetylthiazole boronic ester
EINECS	Contact for details

Quality Control

Our 1-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Thiazol-2-Yl]Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.