Description

3-Chloro-2-Hydroxymethylphenylboronic Acid is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its dual functionality, where the boronic acid group enables efficient cross-coupling reactions, and the chlorohydroxymethyl moiety offers a handle for further structural elaboration. This compound is essential for research chemists and process development scientists working in pharmaceutical discovery and advanced material science. It is particularly sought after for constructing complex molecular architectures where precise control over substitution patterns is required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Research: Used in creating novel compounds for crop protection and herbicide development.
• Ligand Synthesis: Serves as a starting material for the preparation of specialized ligands used in catalysis and material science.
• Polymer Chemistry: Incorporated into specialty polymers and advanced organic frameworks to impart specific functional properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors for biological research.
• Organic Electronic Materials: A building block for π-conjugated systems in OLEDs and other electronic applications.

Basic Information

Product Name	3-Chloro-2-Hydroxymethylphenylboronic Acid
CAS No.	1451393-57-9
Molecular Formula	C7H8BClO3
Molecular Weight	186.40 g/mol
Synonyms	(3-Chloro-2-(hydroxymethyl)phenyl)boronic acid; 2-(Hydroxymethyl)-3-chlorobenzeneboronic acid; 3-Chloro-2-(hydroxymethyl)benzeneboronic acid; Boronic acid, B-[3-chloro-2-(hydroxymethyl)phenyl]-; 3-Chloro-2-hydroxymethylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Hydroxymethylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated environments, including cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.