Description

2-Chloro-4-Formyl-3-Methylphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl and a boronic acid group on a chlorinated aromatic ring, makes it an indispensable reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced materials. Its reliable performance and consistent quality are essential for accelerating drug discovery pipelines and material science projects.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogen and formyl groups for further functionalization.
• Material Science: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, due to its planar, conjugated potential.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of molecular probes and sensors targeting specific proteins or enzymes.
• Ligand Synthesis for Catalysis: Serves as a starting material for synthesizing novel bidentate or tridentate ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-4-Formyl-3-Methylphenylboronic Acid
CAS No.	1451391-36-8
Molecular Formula	C9H8BClO3
Molecular Weight	210.42 g/mol
Synonyms	(2-Chloro-4-formyl-3-methylphenyl)boronic acid; 2-Chloro-3-methyl-4-formylbenzeneboronic acid; 4-Borono-2-chloro-3-methylbenzaldehyde; 2-Chloro-4-formyl-3-methylbenzeneboronic acid; 2-Chloro-3-methyl-4-carboxaldehydephenylboronic acid; 1451391-36-8; Boronic acid, B-(2-chloro-4-formyl-3-methylphenyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Formyl-3-Methylphenylboronic Acid is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR (1H, 13C, 11B), and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality commitment ensures the material meets the stringent requirements for research and cGMP (current Good Manufacturing Practice) starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.