Description

4-Benzyloxy-2-Piperidine-1-Yl-Pyrimidine-5-Boronic Acid Pinacol Ester is a high-value, advanced pharmaceutical intermediate belonging to the class of protected boronic acid esters. This compound is a critical building block in modern organic synthesis, particularly for the construction of complex molecules via cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing coupling partner for the synthesis of biaryl and heterobiaryl structures, which are common motifs in drug candidates.
• Pharmaceutical Intermediate: Used in the research and development of potential therapeutic agents, including kinase inhibitors and other small molecule drugs.
• Chemical Synthesis Building Block: Enables the efficient introduction of the 4-benzyloxy-2-piperidinyl-pyrimidine moiety into more complex molecular architectures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Used in scaling up synthetic routes for the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Potential application in the synthesis of novel crop protection agents and herbicides.
• Material Science: Can be investigated for the synthesis of organic electronic materials and ligands for catalysts.

Basic Information

Product Name	4-Benzyloxy-2-Piperidine-1-Yl-Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1451391-24-4
Molecular Formula	C22H28BN3O3
Molecular Weight	393.29 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(piperidin-1-yl)-4-(phenylmethoxy)pyrimidine; 4-(Benzyloxy)-2-(1-piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Piperidin-1-yl-4-benzyloxypyrimidine-5-boronic acid pinacol ester; 4-Benzyloxy-2-(1-piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 4-Benzyloxy-2-piperidin-1-ylpyrimidine-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-2-Piperidine-1-Yl-Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical R&D. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards, and specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.