Description

3,5-Difluoro-2-Hydroxyphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing biaryl and heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require the introduction of difluorophenol and boronate ester functionalities.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers, where its structure allows for fine-tuning of electronic properties.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful in constructing molecular probes and tags for studying biological processes, leveraging the stability of the pinacol ester group.

Basic Information

Product Name	3,5-Difluoro-2-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	1451391-16-4
Molecular Formula	C₁₂H₁₅BF₂O₃
Molecular Weight	256.05 g/mol
Synonyms	2-Hydroxy-3,5-difluorophenylboronic acid pinacol ester; (3,5-Difluoro-2-hydroxyphenyl)boronic acid pinacol ester; Pinacol (3,5-difluoro-2-hydroxyphenyl)boronate; 3,5-Difluoro-2-hydroxybenzeneboronic acid pinacol ester; B-(3,5-Difluoro-2-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(3,5-difluoro-2-hydroxyphenyl)-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.