Description

Potassium 5-Methoxypyridine-3-Trifluoroborate is a high-purity organotrifluoroborate salt, a crucial building block in modern synthetic chemistry. Its value lies in its stability and reactivity as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing pyridine-containing heterocycles prevalent in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific methoxypyridine motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable organoboron reagent for palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds under mild conditions.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and metal-organic frameworks (MOFs) for catalytic applications.
• Material Science Research: A building block for creating organic electronic materials, such as those used in OLEDs and conductive polymers.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research.

Basic Information

Item	Details
Product Name	Potassium 5-Methoxypyridine-3-Trifluoroborate
CAS No.	1451390-69-4
Molecular Formula	C6H6BF3KNO
Molecular Weight	221.03 g/mol
Synonyms	Potassium (5-Methoxy-3-pyridyl)trifluoroborate; 5-Methoxy-3-pyridineboronic acid, trifluoroborate potassium salt; 3-Pyridineboronic acid, 5-methoxy-, potassium trifluoroborate (1:1:1); Potassium 5-Methoxypyridin-3-yltrifluoroborate; 5-Methoxypyridine-3-boronic acid potassium trifluoroborate; Potassium 3-Trifluoroboranyl-5-methoxypyridine; 5-Methoxy-3-pyridyltrifluoroborate potassium salt
EINECS	Contact for details

Quality Control

Our Potassium 5-Methoxypyridine-3-Trifluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC for purity assessment, and KF titration for moisture content, to ensure it meets the high standards required for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
¹⁹F NMR Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, methanol, DMF; partially soluble in THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.