Description

Chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II), Min. 98% [Brettphos Palladacycle] is a highly active and air-stable preformed palladium catalyst, renowned for its exceptional performance in challenging cross-coupling reactions. This compound matters because it offers superior catalytic efficiency and selectivity, enabling the synthesis of complex molecules with high yields under mild conditions. It is an indispensable tool for researchers and process chemists in pharmaceutical development, agrochemical research, and advanced materials science, where reliable and robust catalysis is critical.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key C–N, C–O, and C–C bond-forming reactions, such as Buchwald-Hartwig aminations and Suzuki-Miyaura couplings, for active pharmaceutical ingredient (API) development.
• Agrochemical Research: Facilitating the construction of complex heterocyclic and aromatic compounds used in novel pesticide and herbicide discovery.
• Materials Science: Catalyzing polymerization reactions and the synthesis of conjugated organic materials for electronic and optoelectronic applications.
• Process Chemistry & Scale-up: Serving as a preferred catalyst for process optimization and pilot-scale manufacturing due to its stability and consistent performance.
• Academic & Industrial R&D: A staple catalyst in laboratory settings for methodological development and exploring new synthetic pathways in organic chemistry.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring precise catalytic transformations.

Basic Information

Product Name	Chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II), Min. 98% [Brettphos Palladacycle]
CAS No.	1451002-39-3
Molecular Formula	C53H70ClNO2PPd
Molecular Weight	942.94 g/mol
Synonyms	BrettPhos Palladacycle; Chloro[2'-(dicyclohexylphosphino)-3,6-dimethoxy-2,4,6-triisopropyl-1,1'-biphenyl][2-(2'-aminobiphenyl)]palladium(II); BrettPhos Precatalyst; Gen 3 BrettPhos Pd G3; Pd-PEPPSI-IPent(An)Cl; Palladacycle BrettPhos Catalyst; [2-(2-Aminobiphenyl)]chloro[2'-(dicyclohexylphosphino)-3,6-dimethoxy-2,4,6-triisopropyl-1,1'-biphenyl]palladium(II)
EINECS	Contact for details

Quality Control

Our Brettphos Palladacycle is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including HPLC assay to confirm a minimum purity of 98%, alongside tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications to support your quality management systems and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange-brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 98.0%
Loss on Drying	Max. 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.