Description

3-(But-3-Yn-1-Yl)-3-(2-Iodoethyl)-3H-Diazirine is a specialized, photoactivatable crosslinking reagent belonging to the diazirine class of compounds. This high-purity chemical is critical for advanced research in chemical biology and proteomics, enabling the study of biomolecular interactions and protein structures. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in photoaffinity labeling and target identification.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent crosslinking in the study of protein-ligand, protein-protein, and protein-nucleic acid interactions upon UV light activation.
• Chemical Proteomics: Used to create functionalized probes for identifying and validating drug targets and mapping binding sites within complex biological systems.
• Bioconjugation: Serves as a versatile building block for synthesizing photo-crosslinkable probes, tags, and linkers for biomolecule conjugation.
• Materials Science Research: Applied in the development of novel photo-responsive polymers and smart materials where controlled, light-induced crosslinking is required.
• Structural Biology: Facilitates the stabilization of transient molecular complexes for analysis via techniques like mass spectrometry and cryo-electron microscopy.

Basic Information

Product Name	3-(But-3-Yn-1-Yl)-3-(2-Iodoethyl)-3H-Diazirine
CAS No.	1450754-38-7
Molecular Formula	C7H9IN2
Molecular Weight	248.06 g/mol
Synonyms	3-(But-3-yn-1-yl)-3-(2-iodoethyl)diazirine; 3-(2-Iodoethyl)-3-(but-3-yn-1-yl)diazirine; 3H-Diazirine, 3-(3-butyn-1-yl)-3-(2-iodoethyl)-; Diazirine-based photo-crosslinker; Alkyne- and iodo-functionalized diazirine; Photoactivatable alkyne probe; Bifunctional crosslinking reagent.
EINECS	Contact for details

Quality Control

Our 3-(But-3-Yn-1-Yl)-3-(2-Iodoethyl)-3H-Diazirine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity for sensitive research applications. We guarantee purity levels suitable for advanced chemical biology work. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maximize stability. This compound is strictly light-sensitive and must be handled under subdued light or in amber glass vials to prevent premature decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Light-sensitive liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Contact for higher grades)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.