Description

2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, synthetically versatile boronic ester derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a key building block in modern organic synthesis, particularly in cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors who require precise and reliable synthetic pathways.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A pivotal reagent for constructing biaryl and heterobiaryl structures central to drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Medicinal Chemistry: Utilized in the design and synthesis of molecular probes and candidate drug molecules.
• Custom Synthesis & Contract Manufacturing: A key starting material for bespoke chemical synthesis services.

Basic Information

Product Name	2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1449475-29-9
Molecular Formula	C13H15BClNO2
Molecular Weight	263.53 g/mol
Synonyms	2-Chloro-6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-Chloro-6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-Chloro-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-Chloro-6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; Benzonitrile, 2-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; (6-Cyano-3-chlorophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.