Description

n-(3-Hydroxy-Propyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, making it a critical building block for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in drug discovery and development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality boronic acid derivatives for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Drug Discovery & Medicinal Chemistry: Used in library synthesis for creating diverse compound collections to screen for new biological activities.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials and polymers.
• Chemical Biology & Bioconjugation: Utilized for labeling and modifying biomolecules due to its reactive boronate handle.
• Process Chemistry & Scale-up: Provides a stable and handleable boronate source for optimizing manufacturing routes for complex molecules.

Basic Information

Product Name	n-(3-Hydroxy-Propyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide
CAS No.	1449134-30-8
Molecular Formula	C16H24BNO4
Molecular Weight	305.18 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(3-hydroxypropyl)benzamide; 3-Hydroxypropyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 4-Pinacolatoboryl-N-(3-hydroxypropyl)benzamide; Benzamide, N-(3-hydroxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[4-[[(3-hydroxypropyl)amino]carbonyl]phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of n-(3-Hydroxy-Propyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity, meeting the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.