Description

1-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzyl]-Pyrrolidine-2,5-Dione (CAS NO 1449132-28-8) is a high-value, functionalized organic building block that combines a maleimide core with a protected boronic ester moiety. This compound is critical for advanced organic synthesis, particularly in the development of pharmaceuticals and functional materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications requiring precise molecular coupling and functionalization.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted therapies and bioconjugates.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for constructing complex biaryl and heterobiaryl structures central to drug discovery.
• Bioconjugation and Protein Labeling: The maleimide group enables selective thiol-Michael addition for attaching payloads, probes, or linkers to proteins, antibodies, or peptides.
• Polymer and Material Science: Used in the synthesis of functional polymers, dendrimers, and advanced materials where precise boronic acid or maleimide functionality is required.
• Chemical Biology Probe Development: Facilitates the creation of activity-based probes and diagnostic agents for studying biological pathways.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	1-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzyl]-Pyrrolidine-2,5-Dione
CAS No.	1449132-28-8
Molecular Formula	C17H22BNO4
Molecular Weight	315.18 g/mol
Synonyms	1-[(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]-2,5-pyrrolidinedione; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Maleimide; N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]maleimide; 1-(4-(Pinacolatoboryl)benzyl)pyrrolidine-2,5-dione; 4-(Pinacolatoboryl)benzyl Maleimide; Maleimide-PEG4-Boronic Acid Pinacol Ester (related); B-(4-((2,5-Dioxo-1-pyrrolidinyl)methyl)phenyl)boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzyl]-Pyrrolidine-2,5-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.