Description

2-(1H-Pyrazol-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is valued for its role in facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry and materials science. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology: Employed in the design and synthesis of molecular probes and bio-conjugates for target identification and validation.
• Library Synthesis: A versatile reagent for generating diverse compound libraries in high-throughput screening and drug discovery campaigns.
• Catalyst Ligand Synthesis: Used to construct complex heterocyclic ligands for transition metal catalysis.

Basic Information

Product Name	2-(1H-Pyrazol-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1449009-97-5
Molecular Formula	C₁₃H₁₇BN₄O₂
Molecular Weight	272.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1H-pyrazol-1-yl)pyrimidine; 2-(1H-Pyrazol-1-yl)pyrimidine-5-boronic acid pinacol ester; 2-(1-Pyrazolyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Pyrimidine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1H-pyrazol-1-yl)-; 1449009-97-5
EINECS	Contact for details

Quality Control

Our 2-(1H-Pyrazol-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.