Description

1-(2-Amino-4-Chlorophenyl)-2,2,2-Trifluoroethan-1-One, 5-Chloro-2-(Trifluoroacetyl)Aniline CAS NO 1448858-54-5 is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoroacetyl aniline structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those requiring a halogenated aromatic backbone with a reactive amine group. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for constructing novel molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in therapeutic areas targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group contributes to lipophilicity and biological efficacy.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic materials that require fluorinated aromatic components.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Organic Synthesis Reagent: A versatile reagent for introducing the 5-chloro-2-(trifluoroacetyl)aniline moiety into more complex molecular architectures via coupling reactions.

Basic Information

Product Name	1-(2-Amino-4-Chlorophenyl)-2,2,2-Trifluoroethan-1-One, 5-Chloro-2-(Trifluoroacetyl)Aniline
CAS No.	1448858-54-5
Molecular Formula	C8H5ClF3NO
Molecular Weight	223.58 g/mol
Synonyms	5-Chloro-2-(trifluoroacetyl)aniline; 2-Amino-4-chloro-α,α,α-trifluoroacetophenone; 1-(2-Amino-4-chlorophenyl)-2,2,2-trifluoroethanone; 4-Chloro-2-amino-α,α,α-trifluoroacetophenone; 2-Amino-4-chloro-α,α,α-trifluoroacetophenone; 5-Chloro-α,α,α-trifluoro-2-aminoacetophenone; 1448858-54-5
EINECS	Contact for details

Quality Control

Our production of 1-(2-Amino-4-Chlorophenyl)-2,2,2-Trifluoroethan-1-One adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.