Description

Palladium[2'-(Amino-κn)[1,1'-Biphenyl]-2-Yl-κc]2'-(Diphenylphosphino-κp)-N2,N2,N6,N6-Tetramethyl[1,1'-Biphenyl]-2,6-Diamine- is a sophisticated, air-stable monophosphine palladacycle pre-catalyst designed for high-performance cross-coupling reactions. This compound matters because it offers exceptional catalytic activity and selectivity, enabling more efficient and sustainable synthetic routes in complex molecule construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications such as C-H activation, Suzuki-Miyaura, and Buchwald-Hartwig amination reactions.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for constructing complex carbon-nitrogen and carbon-carbon bonds in active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective cross-coupling steps.
• Advanced Material Development: Facilitates the synthesis of conjugated polymers and organic electronic materials through efficient coupling reactions.
• Buchwald-Hartwig Amination: Highly effective for the coupling of aryl halides with amines, a cornerstone reaction in medicinal chemistry.
• Suzuki-Miyaura Cross-Coupling: Catalyzes the coupling of aryl/vinyl boronic acids with aryl/vinyl halides for biaryl synthesis.
• C-H Functionalization: Enables direct transformation of C-H bonds into more valuable functional groups, streamlining synthetic sequences.
• Academic & Industrial R&D: A valuable tool for methodological development and exploring new catalytic transformations in laboratory settings.
• Scale-up Process Chemistry: Suitable for optimization and scale-up due to its stability and well-defined catalytic behavior.

Basic Information

Item	Details
Product Name	Palladium[2'-(Amino-κn)[1,1'-Biphenyl]-2-Yl-κc]2'-(Diphenylphosphino-κp)-N2,N2,N6,N6-Tetramethyl[1,1'-Biphenyl]-2,6-Diamine-
CAS No.	1447963-74-7
Molecular Formula	C45H46N3O3PPdS
Molecular Weight	856.30 g/mol
Synonyms	Buchwald Palladacycle G4; Methanesulfonato(2'-amino[1,1'-biphenyl]-2-yl-κC2)(2'-(dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl[1,1'-biphenyl]-2,6-diamine-κP)palladium; Palladium G4 Catalyst; [2'-(Amino-κN)[1,1'-biphenyl]-2-yl-κC]2'-(dicyclohexylphosphino-κP)-N2,N2,N6,N6-tetramethyl[1,1'-biphenyl]-2,6-diaminepalladium; t-BuBrettPhos Pd G4; BrettPhos Pd G4; Pd-PEPPSI type complex; Air-stable Pd precatalyst.
EINECS	Contact for details

Quality Control

Our Palladium[2'-(Amino-κn)[1,1'-Biphenyl]-2-Yl-κc]2'-(Diphenylphosphino-κp)-N2,N2,N6,N6-Tetramethyl[1,1'-Biphenyl]-2,6-Diamine- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for catalytic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance data for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent oxidation and moisture uptake, which can affect catalytic performance. For long-term storage, consider storing in a desiccator.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Pd Content	12.0 - 13.0 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.