Description

6,6-Difluorospiro[2.5]Octane-1-Carboxylic Acid is a high-value, multifunctional fluorinated building block characterized by its unique spirocyclic and difluoro-substituted structure. This compound is essential for advanced organic synthesis, offering chemists a versatile scaffold to modulate the physicochemical properties of target molecules, particularly enhancing metabolic stability and membrane permeability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoro and carboxylic acid motifs contribute to biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, coatings, and advanced materials with tailored surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis, leveraging its rigid three-dimensional geometry.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and for introducing fluorine atoms into complex molecular architectures in academic and industrial R&D settings.
• Peptidomimetics and Bioisosteres: The spirocyclic carboxylic acid structure is used to create conformationally constrained analogs of amino acids or peptide segments in medicinal chemistry.

Basic Information

Product Name	6,6-Difluorospiro[2.5]Octane-1-Carboxylic Acid
CAS No.	1447943-53-4
Molecular Formula	C9H12F2O2
Molecular Weight	190.19 g/mol
Synonyms	6,6-Difluoro-1-spiro[2.5]octane-1-carboxylic acid; 1-Carboxy-6,6-difluorospiro[2.5]octane; Difluorospirooctanecarboxylic acid; Spiro[2.5]octane-1-carboxylic acid, 6,6-difluoro-; 1447943-53-4; 6,6-Difluorospirooctane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development use. Every batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to a strict quality management system to guarantee the reliability and traceability of our fluorinated building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its carboxylic acid nature, keep away from strong bases, oxidizing agents, and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.