Description

Ethyl 1,1-Difluorospiro[2.5]Octane-6-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is critical for medicinal chemists seeking to modulate the physicochemical and metabolic properties of drug candidates, particularly through the strategic incorporation of fluorine atoms. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs) within the life sciences sector.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to improve potency, selectivity, and pharmacokinetic profiles.
• Fluorine Chemistry: Acts as a versatile reagent for introducing difluoromethylene (CF2) groups into organic frameworks, a common strategy in modern drug design.
• Spirocyclic Compound Synthesis: Provides a rigid, three-dimensional spiro[2.5]octane scaffold, which is valuable for creating conformationally constrained analogs with enhanced biological activity.
• Agrochemical Development: Potential application in the synthesis of advanced crop protection agents and pesticides that benefit from fluorinated motifs.
• Material Science Precursor: Can be utilized in the development of specialty polymers or functional materials with specific fluorinated properties.

Basic Information

Product Name	Ethyl 1,1-Difluorospiro[2.5]Octane-6-Carboxylate
CAS No.	1447942-59-7
Molecular Formula	C11H16F2O2
Molecular Weight	218.24 g/mol
Synonyms	6-Carbethoxy-1,1-difluorospiro[2.5]octane; Ethyl 6,6-difluorospiro[2.5]octane-1-carboxylate; 1,1-Difluorospiro[2.5]octane-6-carboxylic acid ethyl ester; Spiro[2.5]octane-6-carboxylic acid, 1,1-difluoro-, ethyl ester; Ethyl 1,1-difluoro-6-spiro[2.5]octanecarboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 1,1-Difluorospiro[2.5]Octane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliable supply for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.