Description

(1R,3S,5S)-Rel-6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique, rigid bicyclic scaffold with strategic fluorine substitution. This compound matters because it serves as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs), where its structure imparts desirable metabolic stability and binding affinity. Pharmaceutical and biotechnology R&D teams need this chiral synthon for the development of next-generation therapeutics, particularly in areas like antiviral and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex, fluorinated active pharmaceutical ingredients (APIs).
• Antiviral Drug Development: Used in research and production of novel antiviral compounds, leveraging the metabolic stability conferred by the difluorinated core.
• CNS-Targeted Therapeutics: Employed in the construction of drug candidates targeting neurological disorders due to the ability of the bicyclo[3.1.0]hexane scaffold to influence blood-brain barrier penetration.
• Medicinal Chemistry & SAR Studies: Provides a versatile, conformationally restricted template for structure-activity relationship (SAR) exploration in drug discovery programs.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the development of robust, scalable synthetic routes for clinical and commercial API manufacturing.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research focused on the synthesis and application of fluorinated organic molecules.

Basic Information

Product Name	(1R,3S,5S)-Rel-6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylic Acid
CAS No.	1447942-40-6
Molecular Formula	C8H8F2O2
Molecular Weight	174.15 g/mol
Synonyms	rel-(1R,3S,5S)-6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid; 6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic Acid (rel-(1R,3S,5S)-); Bicyclo[3.1.0]hexane-3-carboxylic acid, 6,6-difluoro-, (1R,3S,5S)-rel-; (1R,3S,5S)-6,6-Difluoro-3-bicyclo[3.1.0]hexanecarboxylic Acid; Difluorinated Bicyclo[3.1.0]hexane Carboxylic Acid Derivative; CAS 1447942-40-6
EINECS	Contact for details

Quality Control

Our (1R,3S,5S)-Rel-6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is sensitive to strong alkali and fluorides; keep away from incompatible substances. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.