Description

4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)phenylboronic acid pinacol ester is a high-purity, advanced pharmaceutical intermediate and versatile organoboron building block. This compound is essential for facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the construction of complex biaryl and heterobiaryl structures. The pinacol ester group enhances stability and handling, making it a reliable reagent for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targeted drugs and kinase inhibitors.
• Suzuki-Miyaura Cross-Coupling: A critical reagent for forming carbon-carbon bonds between aromatic rings, enabling the construction of complex molecular architectures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific biaryl motifs.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in OLED displays.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes and labeled compounds for biological target identification and mechanism-of-action studies.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis of diverse compound libraries for screening in early-stage drug discovery programs.

Basic Information

Product Name	4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)phenylboronic acid pinacol ester
CAS No.	1447696-00-5
Molecular Formula	C18H26BNO2
Molecular Weight	299.22 g/mol
Synonyms	4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)benzeneboronic acid pinacol ester; 4-(1-Methyl-4-piperidinyl)phenylboronic acid pinacol ester; [4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]boronic acid pinacol ester; B-[4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-5,5-dimethyl-1,3,2-dioxaborinane; 4-(N-Methyl-1,2,3,6-tetrahydropyridin-4-yl)phenylboronic acid pinacol ester; CAS 1447696-00-5; Boronic ester derivative of 4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)aniline
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Quality Control

Our 4-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)phenylboronic acid pinacol ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.