Description

5-Bromo-2-Fluoro-1-(1,1,2,2,2-Pentafluoroethyl)-Benzene is a high-value fluorinated aromatic building block, distinguished by its unique combination of bromine, fluorine, and a pentafluoroethyl group. This compound is engineered to provide exceptional reactivity and stability, making it a critical intermediate for advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for constructing complex molecules, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and introducing the pentafluoroethyl group into novel molecular architectures.
• Advanced Polymer Modification: Employed to incorporate fluorine into polymer backbones to enhance chemical resistance, thermal stability, and surface properties.

Basic Information

Product Name	5-Bromo-2-Fluoro-1-(1,1,2,2,2-Pentafluoroethyl)-Benzene
CAS No.	1447671-80-8
Molecular Formula	C8H3BrF6
Molecular Weight	292.99 g/mol
Synonyms	1-Bromo-4-fluoro-2-(pentafluoroethyl)benzene; 2-Bromo-5-fluoro-1-(pentafluoroethyl)benzene; 5-Bromo-2-fluoro-1-(pentafluoroethyl)benzene; 2-Fluoro-5-bromo-α,α,α,α',α'-pentafluoroethylbenzene; 1-(Pentafluoroethyl)-5-bromo-2-fluorobenzene; Benzene, 5-bromo-2-fluoro-1-(1,1,2,2,2-pentafluoroethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-1-(1,1,2,2,2-Pentafluoroethyl)-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.