Description

1-(Fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the pyrazole heterocycle with a fluoromethyl handle into target molecules, facilitating the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in creating novel fungicides, herbicides, and insecticides by incorporating the pyrazole moiety into lead compounds.
• Material Science: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials via cross-coupling polymerization or functionalization.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorescent probes, enzyme inhibitors, and other tools for biochemical and cellular research.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic & R&D Laboratories: Fundamental reagent for methodological development in organic synthesis and catalysis research at universities and corporate R&D centers.

Basic Information

Product Name	1-(Fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
CAS No.	1446481-36-2
Molecular Formula	C10H16BFN2O2
Molecular Weight	226.06 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(fluoromethyl)-1H-pyrazole; 1-(Fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-(Fluoromethyl)-4-(pinacolato)pyrazole; 1-(Fluoromethyl)-4-(pinacolatoboryl)pyrazole; 1-(Fluoromethyl)pyrazole-4-boronic acid pinacol ester; 4-Borono-1-(fluoromethyl)-1H-pyrazole pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 1-(Fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize moisture uptake. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.