Description

2-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is a high-value organoboron building block, specifically a thiazole-substituted pinacol boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing complex carbon-carbon bonds under mild conditions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiazole heterocycles.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific thiazole motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where conjugated thiazole systems are valuable.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile reagent for creating molecular probes and libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Catalyst & Ligand Development: Acts as a precursor for synthesizing novel ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke organic compounds for client projects.

Basic Information

Product Name	2-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole
CAS No.	1446481-20-4
Molecular Formula	C12H20BNO2S
Molecular Weight	253.17 g/mol
Synonyms	2-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isopropylthiazole; 2-Isopropylthiazole-5-boronic acid pinacol ester; Thiazole-5-boronic acid, 2-(1-methylethyl)-, 1,1-dimethylethyl ester; 1446481-20-4; 2-Isopropyl-5-(pinacolatoboryl)thiazole; 5-(Pinacolatoboryl)-2-isopropylthiazole
EINECS	Contact for details

Quality Control

Our production of 2-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized by NMR (1H, 13C, 11B), HPLC, and GC analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.